Thermal Properties of Deoxyribonucleic Acids from Sensitive and Resistant Plasmacytomas1
نویسندگان
چکیده
cate that cellular deoxyribonucleic acid (DNA) might be the primary and perhaps the critical site of alkylation by cytotoxic alkylating agents (21). The biologic systems used in most of these investigations, however, have not permitted a direct correlation between alkylation of DNA and the observed biologic effects; that is, there is a lack of evidence whether alkylation of DNA is essential to the biologic effect. The availability of an alkylating agent sensitive tumor and a sublime of the tumor that is resistant to the respective agent offers the opportunity for attempt
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